The Penguins gave up two goals in the final 42 seconds, then held off the Sabres for a 5-4 win at the PPG Paints Arena.
Jake Guentzel had a goal and two assists, and Conor Sheary assisted on three goals. Sidney Crosby scored his first goal of the preseason.
The regular season begins next Wednesday when the Pens host the St. Louis Blues.
