The Pirates rallied from a five-run deficit but fell short in a 7-6 extra-inning loss to the Cubs, who clinched a playoff spot.
Corey Dickerson and Jose Osuna homered for Pittsburgh.
The series ends tonight with Trevor Williams opposing Jon Lester.
Pregame is at 7:40 p.m. on WCCS AM 1160 and 101.1 FM.
